Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma
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چکیده
منابع مشابه
Transposon Mutagenesis Screen Identifies Potential Lung Cancer
40 Non-small cell lung cancers (NSCLCs) harbor thousands of passenger events that hide genetic 41 drivers. Even highly recurrent events in NSCLC, such as mutations in PTEN, EGFR, KRAS, and ALK, 42 are only detected in, at most, 30% of patients. Thus, many unidentified low-penetrant events are causing 43 a significant portion of lung cancers. To detect low-penetrance drivers of NSCLC a forward g...
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UNLABELLED Non-small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent events in NSCLC, such as mutations in PTEN, EGFR, KRAS, and ALK, are detected, at most, in only 30% of patients. Thus, many unidentified low-penetrant events are causing a significant portion of lung cancers. To detect low-penetrance drivers of NSCLC, a forward ge...
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Despite considerable efforts to sequence hypermutated cancers such as melanoma, distinguishing cancer-driving genes from thousands of recurrently mutated genes remains a significant challenge. To circumvent the problematic background mutation rates and identify new melanoma driver genes, we carried out a low-copy piggyBac transposon mutagenesis screen in mice. We induced eleven melanomas with m...
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Uropathogenic Escherichia coli (UPEC), which accounts for 85% of urinary tract infections (UTI), assembles biofilms in diverse environments, including the host. Besides forming biofilms on biotic surfaces and catheters, UPEC has evolved an intracellular pathogenic cascade that culminates in the formation of biofilm-like intracellular bacterial communities (IBCs) within bladder epithelial cells....
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Gametocytes are essential for Plasmodium transmission, but little is known about the mechanisms that lead to their formation. Using piggyBac transposon-mediated insertional mutagenesis, we screened for parasites that no longer form mature gametocytes, which led to the isolation of 29 clones (insertional gametocyte-deficient mutants) that fail to form mature gametocytes. Additional analysis reve...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2015
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.3275